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Selected publications

Kandiba L, Aitio O, Helin J, Guan Z, Permi P, Bamford DH, Eichler J, Roine E. Diversity in prokaryotic glycosylation: an archaeal-derived N-linked glycan contains legionaminic acid. Mol Microbiol. 2012 May;84(3):578-93.

Hirvonen T, Suila H, Kotovuori A, Ritamo I, Heiskanen A, Sistonen P, Anderson H, Satomaa T, Saarinen J, Tiitinen S, Räbinä J, Laitinen S, Natunen S, Valmu L. The i blood group antigen as a marker for umbilical cord blood-derived mesenchymal stem cells. Stem Cells Dev. 2012 Feb 10;21(3):455-64.

Natunen S, Satomaa T, Pitkänen V, Salo H, Mikkola M, Natunen J, Otonkoski T, Valmu L. The binding specificity of the marker antibodies Tra-1-60 and Tra-1-81 reveals a novel pluripotency-associated type 1 lactosamine epitope. Glycobiology. 2011 Sep;21(9):1125-30.

Suila H, Pitkänen V, Hirvonen T, Heiskanen A, Anderson H, Laitinen A, Natunen S, Miller-Podraza H, Satomaa T, Natunen J, Laitinen S, Valmu L. Are globoseries glycosphingolipids SSEA-3 and -4 markers for stem cells derived from human umbilical cord blood? J Mol Cell Biol. 2011 Apr;3(2):99-107.

Satomaa T, Heiskanen A, Leonardsson I, Angström J, Olonen A, Blomqvist M, Salovuori N, Haglund C, Teneberg S, Natunen J, Carpén O, Saarinen J. Analysis of the human cancer glycome identifies a novel group of tumor-associated N-acetylglucosamine glycan antigens. Cancer Res. 2009 Jul 15;69(14):5811-9.

Satomaa T, Heiskanen A, Mikkola M, Olsson C, Blomqvist M, Tiittanen M, Jaatinen T, Aitio O, Olonen A, Helin J, Hiltunen J, Natunen J, Tuuri T, Otonkoski T, Saarinen J, Laine J. The N-glycome of human embryonic stem cells. BMC Cell Biol. 2009 Jun 2;10:42.

Hernandez Mir G, Helin J, Skarp KP, Cummings RD, Mäkitie A, Renkonen R, Leppänen A. Glycoforms of human endothelial CD34 that bind L-selectin carry sulfated sialyl Lewis x capped O- and N-glycans. Blood. 2009 Jul 16;114(3):733-41.

Miller-Podraza H, Weikkolainen K, Larsson T, Linde P, Helin J, Natunen J, Karlsson KA. Helicobacter pylori binding to new glycans based on N-acetyllactosamine. Glycobiology. 2009 Apr;19(4):399-407.

Heiskanen A, Hirvonen T, Salo H, Impola U, Olonen A, Laitinen A, Tiitinen S, Natunen S, Aitio O, Miller-Podraza H, Wuhrer M, Deelder AM, Natunen J, Laine J, Lehenkari P, Saarinen J, Satomaa T, Valmu L. Glycomics of bone marrow-derived mesenchymal stem cells can be used to evaluate their cellular differentiation stage. Glycoconj J. 2009 Apr;26(3):367-84.

Itkonen O, Helin J, Saarinen J, Kalkkinen N, Ivanov KI, Stenman UH, Valmu L. Mass spectrometric detection of tyrosine sulfation in human pancreatic trypsinogens, but not in tumor-associated trypsinogen. FEBS J. 2008 Jan;275(2):289-301.

Hemmoranta H, Satomaa T, Blomqvist M, Heiskanen A, Aitio O, Saarinen J, Natunen J, Partanen J, Laine J, Jaatinen T. N-glycan structures and associated gene expression reflect the characteristic N-glycosylation pattern of human hematopoietic stem and progenitor cells. Exp Hematol. 2007 Aug;35(8):1279-92.

Heiskanen A, Satomaa T, Tiitinen S, Laitinen A, Mannelin S, Impola U, Mikkola M, Olsson C, Miller-Podraza H, Blomqvist M, Olonen A, Salo H, Lehenkari P, Tuuri T, Otonkoski T, Natunen J, Saarinen J, Laine J. N-glycolylneuraminic acid xenoantigen contamination of human embryonic and mesenchymal stem cells is substantially reversible. Stem Cells. 2007 Jan;25(1):197-202.

Ravanko K, Järvinen K, Helin J, Kalkkinen N, Hölttä E. Cysteine cathepsins are central contributors of invasion by cultured adenosylmethionine decarboxylase-transformed rodent fibroblasts. Cancer Res. 2004 Dec 15;64(24):8831-8.

Ylönen A, Helin J, Bøgwald J, Jaakola A, Rinne A, Kalkkinen N. Purification and characterization of novel kininogens from spotted wolffish and Atlantic cod. Eur J Biochem. 2002 Jun;269(11):2639-46.

Karisola P, Alenius H, Mikkola J, Kalkkinen N, Helin J, Pentikäinen OT, Repo S, Reunala T, Turjanmaa K, Johnson MS, Palosuo T, Kulomaa MS. The major conformational IgE-binding epitopes of hevein (Hev b6.02) are identified by a novel chimera-based allergen epitope mapping strategy. J Biol Chem. 2002 Jun 21;277(25):22656-61.

Satomaa T, Renkonen O, Helin J, Kirveskari J, Mäkitie A, Renkonen R. O-glycans on human high endothelial CD34 putatively participating in L-selectin recognition. Blood. 2002 Apr 1;99(7):2609-11.

Ylönen A, Kalkkinen N, Saarinen J, Bøgwald J, Helin J. Glycosylation analysis of two cysteine proteinase inhibitors from Atlantic salmon skin: di-O-acetylated sialic acids are the major sialic acid species on N-glycans. Glycobiology. 2001 Jul;11(7):523-31.

Seppälä U, Majamaa H, Turjanmaa K, Helin J, Reunala T, Kalkkinen N, Palosuo T. Identification of four novel potato (Solanum tuberosum) allergens belonging to the family of soybean trypsin inhibitors. Allergy. 2001 Jul;56(7):619-26.

Leppänen A, White SP, Helin J, McEver RP, Cummings RD. Binding of glycosulfopeptides to P-selectin requires stereospecific contributions of individual tyrosine sulfate and sugar residues. J Biol Chem. 2000 Dec 15;275(50):39569-78.

Oppermann M, Cols N, Nyman T, Helin J, Saarinen J, Byman I, Toran N, Alaiya AA, Bergman T, Kalkkinen N, Gonzàlez-Duarte R, Jörnvall H. Identification of foetal brain proteins by two-dimensional gel electrophoresis and mass spectrometry comparison of samples from individuals with or without chromosome 21 trisomy. Eur J Biochem. 2000 Aug;267(15):4713-9.

Leppänen A, Mehta P, Ouyang YB, Ju T, Helin J, Moore KL, van Die I, Canfield WM, McEver RP, Cummings RD. A novel glycosulfopeptide binds to P-selectin and inhibits leukocyte adhesion to P-selectin. J Biol Chem. 1999 Aug 27;274(35):24838-48.

Kuliopulos A, Covic L, Seeley SK, Sheridan PJ, Helin J, Costello CE. Plasmin desensitization of the PAR1 thrombin receptor: kinetics, sites of truncation, and implications for thrombolytic therapy. Biochemistry. 1999 Apr 6;38(14):4572-85.

Saarinen J, Welgus HG, Flizar CA, Kalkkinen N, Helin J. N-glycan structures of matrix metalloproteinase-1 derived from human fibroblasts and from HT-1080 fibrosarcoma cells. Eur J Biochem. 1999 Feb;259(3):829-40.

Helin J, Caldentey J, Kalkkinen N, Bamford DH. Analysis of the multimeric state of proteins by matrix assisted laser desorption/ionization mass spectrometry after cross-linking with glutaraldehyde. Rapid Commun Mass Spectrom. 1999;13(3):185-90.

Harjunpää V, Helin J, Koivula A, Siika-aho M, Drakenberg T. A comparative study of two retaining enzymes of Trichoderma reesei: transglycosylation of oligosaccharides catalysed by the cellobiohydrolase I, Cel7A, and the beta-mannanase, Man5A. FEBS Lett. 1999 Jan 25;443(2):149-53.

Nyman TA, Kalkkinen N, Tölö H, Helin J. Structural characterisation of N-linked and O-linked oligosaccharides derived from interferon-alpha2b and interferon-alpha14c produced by Sendai-virus-induced human peripheral blood leukocytes. Eur J Biochem. 1998 Apr 15;253(2):485-93.

Popham DL, Helin J, Costello CE, Setlow P. Muramic lactam in peptidoglycan of Bacillus subtilis spores is required for spore outgrowth but not for spore dehydration or heat resistance. Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15405-10.

Popham DL, Helin J, Costello CE, Setlow P. Analysis of the peptidoglycan structure of Bacillus subtilis endospores. J Bacteriol. 1996 Nov;178(22):6451-8.